Timeline of Key Events

The Spanish conquest was not just one event, but a series of turning points that changed the Americas forever. From Columbus’s first voyage to the fall of the Inca Empire, each moment shaped the lives of millions and left a lasting impact on history. This timeline shows the key events that tell the story of those years.

1492 Atlantic voyage
1492 Christopher Columbus reaches the Caribbean.

He sails west for Spain and lands on Caribbean islands. He claims lands and people for Spain.

1519 Cortés lands
1519 Cortés lands in Mexico.

He makes alliances with Indigenous groups who oppose the Aztec Empire.

1520 smallpox
1520 Smallpox epidemic.

The disease spreads through central Mexico and kills many, including Moctezuma II.

1521 fall of Tenochtitlan
1521 Fall of Tenochtitlan.

Cortés and Indigenous allies defeat the Aztec capital.

1532 Cajamarca
1532 Pizarro seizes Atahualpa.

At Cajamarca, the Inca ruler is captured during a surprise meeting.

1533 Cuzco
1533 Spanish enter Cuzco.

Atahualpa is executed; the Inca capital is taken.

1542 New Laws
1542 New Laws.

Spain tries to limit abuses in the encomienda system.

1572 Vilcabamba
1572 Vilcabamba falls.

The last Inca stronghold is defeated; Spanish control spreads across the Andes.

Put the events in order

Drag each card into the empty slots from earliest to latest.

1492 — Columbus reaches the Caribbean
1519 — Cortés lands in Mexico
1520 — Smallpox outbreak in Mexico
1521 — Fall of Tenochtitlan
1532 — Pizarro seizes Atahualpa
1533 — Spanish enter Cuzco
1542 — New Laws
1572 — Vilcabamba falls
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